Phosphorylation of RNAPII
نویسندگان
چکیده
منابع مشابه
Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs
Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2 in modulating chromatin features required for regulated developmental gene expression. Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2. Negating Erk1/2 activation leads to increased nucleosome occupancy and decreased occupancy of PRC2 and poised RNAPII at Erk2-PRC2-targ...
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RNA polymerase II generates a diverse set of RNA transcripts, including mRNA, miRNA, lncRNA, and sn(o)RNA. These transcripts are modified and processed in the nucleus by a particular set of enzymes, as illustrated in this SnapShot.
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RecQ helicases are members of an evolutionary conserved family of DNA helicases. They are homologous to the RecQ helicase of E. coli, the founding member of the family. These enzymes include gene products of disease-causing genes in Bloom, Werner, and Rothmund-Thomson syndrome. To date, these proteins have been implicated in many aspects of DNA metabolism, including DNA replication, repair, and...
متن کاملMechanistic Interpretation of Promoter-Proximal Peaks and RNAPII Density Maps
Genome-wide RNA polymerase II (RNAPII) density profiles provide averaged snapshots of transcription but are difficult to interpret in the context of dynamic gene expression. We performed computational modeling to simulate RNAPII density profiles from individual transcription parameters and constructed simple mathematical models to explore general relationships between transcription parameters a...
متن کاملA single flexible RNAPII-CTD integrates many different transcriptional programs.
The RNAPII-CTD functions as a binding platform for coordinating the recruitment of transcription associated factors. Altering CTD function results in gene expression defects, although mounting evidence suggests that these effects likely vary among species and loci. Here we highlight emerging evidence of species- and loci-specific functions for the RNAPII-CTD.
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ژورنال
عنوان ژورنال: Transcription
سال: 2011
ISSN: 2154-1264,2154-1272
DOI: 10.4161/trns.2.3.15004